[The protective effect of hemagglutinin-specific monoclonal antibodies in experimental influenza infection].
Identifieur interne : 002D76 ( Main/Exploration ); précédent : 002D75; suivant : 002D77[The protective effect of hemagglutinin-specific monoclonal antibodies in experimental influenza infection].
Auteurs : F G Nagieva ; N I Krasnova ; V G Nikulina ; O G AndzhaparidzeSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (isolement et purification), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (isolement et purification), Anticorps monoclonaux (usage thérapeutique), Facteurs temps, Hémagglutinines virales (immunologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Poumon (microbiologie), Souris, Souris de lignée BALB C, Spécificité des anticorps (immunologie), Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Virus de la grippe A (immunologie), Évaluation préclinique de médicament.
- MESH :
- immunologie : Hémagglutinines virales, Infections à Orthomyxoviridae, Spécificité des anticorps, Virus de la grippe A.
- isolement et purification : Anticorps antiviraux, Anticorps monoclonaux.
- microbiologie : Poumon.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- Animaux, Facteurs temps, Infections à Orthomyxoviridae, Souris, Souris de lignée BALB C, Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (isolation & purification), Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (isolation & purification), Antibodies, Viral (therapeutic use), Antibody Specificity (immunology), Drug Evaluation, Preclinical, Hemagglutination Inhibition Tests, Hemagglutinins, Viral (immunology), Influenza A virus (immunology), Lung (microbiology), Mice, Mice, Inbred BALB C, Neutralization Tests, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (therapy), Time Factors.
- MESH :
- chemical , immunology : Hemagglutinins, Viral.
- chemical , isolation & purification : Antibodies, Monoclonal, Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- immunology : Antibody Specificity, Influenza A virus, Orthomyxoviridae Infections.
- microbiology : Lung.
- prevention & control : Orthomyxoviridae Infections.
- therapy : Orthomyxoviridae Infections.
- Animals, Drug Evaluation, Preclinical, Hemagglutination Inhibition Tests, Mice, Mice, Inbred BALB C, Neutralization Tests, Time Factors.
Abstract
Experiments in mice showed a high protective effect of monoclonal antibodies (MCA) to influenza A/Krasnodar/101/59 (H2N2) virus hemagglutinin, possessing neutralizing activity in ovo. A 100% protective effect was observed upon intranasal administration of MCA Kp/101-3 48 hours before infection, and 90% effect upon administration of MCA 96 hours before infection. A 100% therapeutic effect was observed upon intranasal administration of MCA Kp/101-3 less than 24 hours postinfection and 70% therapeutic effect was achieved by administration of these MCA 48-72 hours postinfection.
PubMed: 1891875
Affiliations:
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Le document en format XML
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infection].</title><author><name sortKey="Nagieva, F G" sort="Nagieva, F G" uniqKey="Nagieva F" first="F G" last="Nagieva">F G Nagieva</name></author><author><name sortKey="Krasnova, N I" sort="Krasnova, N I" uniqKey="Krasnova N" first="N I" last="Krasnova">N I Krasnova</name></author><author><name sortKey="Nikulina, V G" sort="Nikulina, V G" uniqKey="Nikulina V" first="V G" last="Nikulina">V G Nikulina</name></author><author><name sortKey="Andzhaparidze, O G" sort="Andzhaparidze, O G" uniqKey="Andzhaparidze O" first="O G" last="Andzhaparidze">O G Andzhaparidze</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (isolation & purification)</term><term>Antibodies, Monoclonal (therapeutic use)</term><term>Antibodies, Viral (isolation & purification)</term><term>Antibodies, 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anticorps</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antibody Specificity</term><term>Influenza A virus</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Evaluation, Preclinical</term><term>Hemagglutination Inhibition Tests</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs temps</term><term>Infections à Orthomyxoviridae</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tests d'inhibition de l'hémagglutination</term><term>Tests de neutralisation</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Experiments in mice showed a high protective effect of monoclonal antibodies (MCA) to influenza A/Krasnodar/101/59 (H2N2) virus hemagglutinin, possessing neutralizing activity in ovo. A 100% protective effect was observed upon intranasal administration of MCA Kp/101-3 48 hours before infection, and 90% effect upon administration of MCA 96 hours before infection. A 100% therapeutic effect was observed upon intranasal administration of MCA Kp/101-3 less than 24 hours postinfection and 70% therapeutic effect was achieved by administration of these MCA 48-72 hours postinfection.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Andzhaparidze, O G" sort="Andzhaparidze, O G" uniqKey="Andzhaparidze O" first="O G" last="Andzhaparidze">O G Andzhaparidze</name><name sortKey="Krasnova, N I" sort="Krasnova, N I" uniqKey="Krasnova N" first="N I" last="Krasnova">N I Krasnova</name><name sortKey="Nagieva, F G" sort="Nagieva, F G" uniqKey="Nagieva F" first="F G" last="Nagieva">F G Nagieva</name><name sortKey="Nikulina, V G" sort="Nikulina, V G" uniqKey="Nikulina V" first="V G" last="Nikulina">V G Nikulina</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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